What does progesterone do?
ArticlesFemale Health

What does progesterone do?

Last updated: 5 June 2026

Progesterone is one of the key hormones involved in reproductive health and overall wellbeing. While it is often associated with pregnancy and the menstrual cycle, its influence extends much further, affecting mood, sleep, bone health and general hormonal balance.

Understanding what progesterone does can help make sense of changes in your cycle, energy levels and wider health, particularly during perimenopause and menopause.

Below, we explore the role of progesterone, what affects its levels and how you can support healthy balance.

##What is progesterone?

Progesterone is a hormone produced mainly in the ovaries after ovulation. It is also made in smaller amounts by the adrenal glands and, during pregnancy, by the placenta.

It works alongside oestrogen to regulate the menstrual cycle and prepare the body for pregnancy. After ovulation, progesterone levels rise to support a potential fertilised egg. If pregnancy does not occur, levels fall and the menstrual period begins.

While oestrogen is often seen as the “building” hormone, progesterone plays a balancing and stabilising role.

##What does progesterone do in the body?

Progesterone has several important functions that extend beyond fertility.

Regulates the menstrual cycle

Progesterone helps control the second half of the menstrual cycle, known as the luteal phase. It prepares the uterus for pregnancy and helps maintain a regular cycle when levels are balanced.

If progesterone is low, cycles may become shorter, irregular or more unpredictable.

Supports pregnancy If conception occurs, progesterone helps maintain the uterine lining so the pregnancy can develop. It also helps prevent contractions in the early stages of pregnancy, supporting a stable environment for the embryo.

Influences mood and wellbeing Progesterone interacts with brain chemicals that influence mood, including GABA, a natural calming chemical in the brain. When levels fluctuate or drop, particularly during perimenopause, some people notice increased anxiety, irritability or mood swings.

Supports sleep quality Progesterone has a natural sedative effect in the body. It can support deeper sleep and help regulate sleep cycles. Low levels may contribute to difficulty falling asleep or staying asleep.

Supports bone health Alongside oestrogen, progesterone plays a role in maintaining bone density. It helps support the bone rebuilding process, particularly in women as they age.

Balances oestrogen One of progesterone’s key roles is balancing the effects of oestrogen. When this balance is disrupted, symptoms such as heavy periods, bloating or mood changes may occur.

##What causes progesterone levels to change?

Progesterone levels naturally fluctuate throughout life and the menstrual cycle. However, several factors can influence whether levels become too low or imbalanced.

Normal menstrual cycle changes Progesterone rises after ovulation and falls before menstruation. If ovulation does not occur, progesterone may remain low throughout the cycle.

Perimenopause and menopause As women approach menopause, ovulation becomes less regular. This leads to reduced progesterone production and can cause symptoms such as irregular periods, sleep disruption and mood changes.

Stress Chronic stress can affect hormone production by diverting resources towards cortisol production. This may interfere with regular ovulation and reduce progesterone levels.

Thyroid imbalance Thyroid function is closely linked to reproductive hormones. An underactive or overactive thyroid can disrupt ovulation and progesterone production.

Polyendocrine metabolic ovarian syndrome Polyendocrine metabolic ovarian syndrome can affect ovulation, which may result in lower progesterone levels.

Body weight and lifestyle factors Significant weight changes, excessive exercise or poor nutrition can disrupt ovulation and hormone balance.

##Signs of low progesterone

Low progesterone can present in several ways, although symptoms can overlap with other hormonal changes.

Common signs include:

  • Irregular or short menstrual cycles
  • Spotting before periods
  • Difficulty sleeping
  • Mood changes or anxiety
  • Headaches
  • Low libido
  • Fertility challenges
  • Breast tenderness

If symptoms persist, hormone testing can help identify whether progesterone imbalance is a factor.

##Why progesterone balance matters

Progesterone does not work in isolation. It interacts closely with oestrogen and other hormones in the endocrine system.

When progesterone levels are too low in relation to oestrogen, it can contribute to symptoms such as heavy periods, bloating, mood swings and disrupted sleep.

Maintaining balance between these hormones is key for overall wellbeing, particularly during midlife hormonal transitions.

##How to support healthy progesterone levels

While hormone levels naturally change over time, there are ways to support overall balance.

Support regular ovulation - Healthy ovulation is essential for progesterone production. Maintaining a balanced diet, managing stress and avoiding extreme dieting can support this process.

Manage stress levels - Reducing chronic stress can help support the endocrine system. Regular movement, relaxation techniques and consistent sleep routines may all help.

Eat a balanced diet - Nutrients such as vitamin B6, magnesium and zinc play a role in hormone production. A varied diet with whole foods can support overall hormonal health.

Prioritise sleep - Good sleep supports hormone regulation, including progesterone production. A consistent sleep routine can help maintain balance.

Maintain a healthy weight - Being significantly underweight or overweight can affect ovulation and hormone production.

##When to consider a progesterone or hormone test

If you are experiencing symptoms that may be hormone related, testing can provide clarity. A progesterone test alone can be useful, but it is often more helpful when viewed alongside other hormones.

  • Testing may be helpful if you are:
  • Experiencing irregular periods
  • Noticing changes in mood or sleep
  • Trying to understand perimenopause symptoms
  • Experiencing fertility concerns
  • Wanting a clearer picture of hormonal balance

A hormone profile can help identify whether progesterone is within the expected range for your stage of life.

##How Bluecrest Wellness can help

Bluecrest Wellness offers Hormone Profiles that measure key hormones including progesterone. These tests provide a clear overview of your hormonal health and help identify whether imbalances may be contributing to symptoms.

You will receive a detailed results report with clear explanations and guidance, helping you understand what your levels mean and what steps you may want to take next.

Understanding your hormones is an important step in taking control of your health and wellbeing.

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Need help? Call free on 0800 652 2183 to speak to one of our team.
AUTHOR

Anna Jones

Chief Nursing Officer, Bluecrest
As the Chief Nursing Officer at Bluecrest, Anna is committed to driving high quality care and services and ensuring excellent clinical governance and accuracy alongside developing new innovative testing to supporting preventative health. | LinkedIn
REVIEWED BY

Graham Jones

Medical Writer
As a Medical Writer for Bluecrest, Graham has a passion for science communication and is dedicated to making health information clear, accurate, and accessible, turning complex medical information into content that empowers people to take charge of their health and supports preventative care.
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